肝癌组织中PTEN的表达及其与p53、细胞增殖和凋亡的关系
肝细胞,,PTEN；癌，肝细胞；增殖细胞核抗原；凋亡；p53,0引言,1材料和方法,2结果,3讨论,【参考文献】
·研究原著·Expression of PTEN in hepatocellular carcinoma and its relationship with p53, cell proliferation and apoptosis
XU Rui，NAN KeJun，CHEN Lin，GUO Hui，RUAN ZhiPing，ZHANG XiaoZhan
1Department of Oncology, First Hospital, 2Department of Pathology，Medical College， Xian Jiaotong University, Xian 710061, China
【Abstract】 AIM: To investigate the relationship of the expression level of PTEN protein with p53 cell apoptosis and proliferation in hepatocellular carcinoma (HCC) tissue so as to explore its roles in the development of HCC. METHODS: Immunohistochemistry was used to assess the protein expression of PTEN, PCNA and p53 in HCC tissues from 47 cases pathologically confirmed after operation, in adjacent normal liver tissues from 42 cases and in 10 normal liver tissues. TUNEL assay was performed to detect apoptosis in HCC tissues. RESULTS: PTEN protein expression was found in the 10 normal tissues and the adjacent normal liver tissues from the 42 cases while no PTEN protein expression was detected in HCC tissues from 25 cases pathologically confirmed after operation. The expression of PTEN was correlated to the metastasis of HCC and p53 expression. There was no correlation between PTEN protein with apoptosis index and proliferation index. CONCLUSION: PTEN, which acts as a tumor suppressor gene, interacts with p53. The lack of PTEN protein expression in HCC may suggest an important role of PTEN in the progression of HCC. ......
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