Alterations of SOD and TAC in serum and gastric mucosa of atrophic gastritis rat caused by highª²salt hot water

    JIANG Mei£¬ZHANG Li£¬HAI Chunª²Xu£¬QIN Xuª²Jun£¬TAO Mei£¬ZHANG Lingª²Xia£¬CAO Guangª²Zhou

    1Department of Gastroenterology, Xi¬ðan Central Hospital, Xi¬ðan 710003, China, 2Department of Toxicology£¬School of Preventive Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the dynamic variation of superoxide dismutase (SOD) and total antioxidant capacity (TAC) in the process of atrophic gastritis formation caused by over salty hot diet. METHODS: The atrophic gastritis rat model was made by feeding 150 g/L salty water of 55¡æ for 12 weeks. The normal control was fed with pure water of 25¡æ. The rats were killed group by group every 4 weeks and the serum and gastric mucosa were kept to test SOD and TAC. Tissue slice of gastric mucosa was observed under optic microscope. The SOD was tested by improved muriatic acid hydroxylamine method, the total albumen content of stomach homogenate was tested by Lowry¬ðs method and TAC was tested by TAC kits. RESULTS: In the 12th week, the gastric mucosa in rats fed with highª²salt hot water presented with typical pathological change as atrophic gastritis, but this pathological change was absent in control group. SOD and TAC in serum and gastric mucosa had a perfect timeª²effect relation in hotª²salt water group. With the time prolonged, the SOD and TAC decreased significantly in hotª²salt water group. CONCLUSION: Active oxygen damnification plays an important precursory role in the formation and evolution of atrophic gastritis. ......