复方红景天_____复方红景天；肝纤维化；Na+

复方红景天对肝纤维化大鼠肝组织Na+/Ca2+泵、TGFβ1 mRNA表达的影响

http://www.100md.com 《第四军医大学学报》 2005年第17期

复方红景天,,复方红景天；肝纤维化；Na+,Ca2+泵；转化生长因子β1,复方红景天对肝纤维化大鼠肝组织Na+,Ca2+泵、TGFβ1mRNA表达的影响,0引言,1材料和方法,2结果,3讨论

     Effects of compound Rhodiola Sachalinensis A Bor on expression of Na+/Ca2+ exchanger and TGFβ1 mRNA in rats with CCl4induced liver fibrosis

    ZENG WeiZheng, WU XiaoLing, JIANG MingDe, CHEN XiaoBin，QIN JianPing，DENG GuiYing

    1Department of Gastroenterology, General Hospital of Chengdu Command, Chengdu 610083，China，2Department of Gastroenterology，First affiliated Hospital of Chongqing University of Medical Science，Chongqing 400016，China，3Room of Gastroscopy, Chengdu Sixth Peoples Hospital, Chengdu 610051, China

    【Abstract】 AIM: To study the protective effects of compound Rhodiola Sachalinensis A Bor on CCl4induced liver fibrosis in rats and to investigate the probable molecular mechanisms. METHODS: Male SD rats were divided into 3 groups: normal (N), compound Rhodiola Sachalinensis A Bor (T) and model (M) groups. The rats in M group and T group were given 300 mL/L CCl4 (3 mL/kg, 2 times/wk) for 14 weeks and compound Rhodiola Sachalinensis A Bor (0.5 g/kg, po, daily for 14 weeks) was administered to rats in T group. The serum concentration of PCⅢ, CⅣ and HA in rat was assayed with RIA method and the liver tissue sections were assessed by HE, VG and Masson staining methods. The expression of Na+/Ca2+ exchanger (NCX) mRNA, transforming growth factor beta 1 (TGFβ1) mRNA and α1 (Ⅰ) procollagen mRNA in each group were observed with semiquantitative in situ RTPCR. RESULTS: Compared with those in M group, the serum PCⅢ, CⅣ and HA levels in T group markedly decreased by the end of experiment (164.25±45.68 vs 265.54±98.2, 96.73±14.68 vs 159.67±29.64, 289.35±75.68 vs 455.79±113.53, respectively, q=4.26 ......

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