Effectiveness of norepinephrine on patients with circulation function failure following extracorporeal circulation operation

    CUI Qin, ZHAO Rong, ZHENG Xiao, JIN Zhenª²Xiao, WANG Hongª²Bing, ZHOU Gengª²Xu, WEI Xuª²Feng, LIU Songª²Tao

    Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To probe the remedy effectiveness of strong positive vasoactive agents on patients with circulation function failure following extracorporeal circulation. METHODS: With the monitor of electrocardiograph, respiration, blood pressure, central venous pressure and the assistance of breathing machine, 19 patients with circulation function failure after extracorporeal circulation operation were treated with norepinephrine and other strong positive vasoactive agents: Norepinephrine (NE) 0.02-1.0 ¦Ìg/(kg¡¤min) or aramine 0.5-5 ¦Ìg/(kg¡¤min), adrenaline (AD) 0.02-1.0 ¦Ìg/(kg¡¤min), dopamine (DA) 5 ¦Ìg/(kg¡¤min) and dobutamine(DOB) 5 ¦Ìg/(kg¡¤min). The hemodynamic parameters including heart rate (HR), cardiac index (CI), mean pulmonary artery blood pressure (mPAP), systemic vascular resistance(SVR), pulmonary vascular resistance (PVR) and mean artery blood pressure (MAB) were monitored. BUN, Cr, electrolyte, acidª²base balance and urinary volume (UV) were also observed. RESULTS: The hemodynamic parameters and clinical conditions of the 19 patients were improved evidently. MAB, SVR and UV increased significantly but HR, CVP, CI, PVR, BUN, Cr, electrolyte and acidª²base balance did not change strikingly. Seventeen cases survived and 2 of the 19 cases died. CONCLUSION: Strong positive vasoactive agents have satisfactory remedy effectiveness on the patients with circulation function failure post extracorporeal circulation and proper administration will not really affect renal function, electrolyte and acidª²base balance. ......