【摘要】 目的 总结32例前列腺癌患者新辅助治疗(NHT)的作用。方法 32例前列腺癌患者中药物去势17例，手术去势15例，并联合抗雄激素治疗3个月，统计NHT前后前列腺癌体积、肿瘤大小、PSA、FSH、LH和睾酮水平变化。结果 2组NHT后前列腺体积明显变小、肿瘤变小、变软，甚至消失，PSA和睾酮明显下降，药物去势组睾酮水平在耻骨后前列腺癌根治术(RRP)术后2～3个月可恢复正常，而手术去势组RRP术后睾酮呈持续低水平。结论 NHT可明显缩小前列腺体积，降低PSA，有利于手术操作。药物去势对内分泌影响是可逆的，而手术去势内分泌改变不可逆。

    【关键词】 前列腺肿瘤；癌；新辅助治疗

    Neoadjuvant hormonal therapy of prostate cancer:a report of 32 cases

    LIU Ding-yi,TANG Qi,WANG Jian,et al.Department of Urology,Punan Hospital,Shanghai 200125,China

    【Abstract】 Objective To summarize the therapeutic effect of neoadjuvant hormonal therapy for prostate cancer in 32 cases.Methods Medical castration was used in 17cases,other 15 patients received surgical castration.Thereafter,all patients had anti-androgen therapy for 3 months.Then we observed the changes of prostate volume,tumor capacity,PSA,FSH,LH and testosterone level.Results After NHT the prostate became smaller,the tumor got softer and even disappeared in both groups.The PSA and testosterone level also decreased.In medical castration group,the testosterone become normally after 2～3 months of RRP.Though in surgical group,the testosterone level was low.Conclusion NHT could decrease the cancer capacity and PSA level so as to profit the operation.The influence of medical castration to the endocrine secretion is reversible and the surgical castration is not. ......