【摘要】 目的 评价三维立体适形放疗联合TP方案同步治疗不可切除ⅢAN2期非小细胞肺癌的疗效和毒性。方法 64例ⅢAN2期非小细胞肺癌患者随机进入三维立体适形放疗联合TP方案组(30例)及普通放疗联合TP方案组(34例)。放射治疗剂量为66Gy。化疗方案：紫杉醇60mg/(m2·d)，d1；顺铂25mg/(m2·d)，d1～3。4周为1个周期。结果 64例全部完成治疗计划，三维立体适形放疗联合组、普通放疗联合组总有效率分别为83.3%、82.33%；胸痛改善分别为82.4%，52.4%；1年生存率分别为70.0%，67.6%。毒副作用：Ⅲ～Ⅳ度白细胞下降、贫血分别为26.7%，50.0%；3.3%；11.8%，Ⅲ～Ⅳ度放射性食管炎及放射性肺炎分别为3.3%，14.7%；0，8.8%。结论 三维立体适形放疗联合TP方案同步治疗不可切除ⅢAN2期非小细胞肺癌较普通放疗联合TP方案治疗组症状改善明显，毒副作用减轻，生存质量提高。

    【关键词】 非小细胞肺癌；三维立体适形放疗；化学疗法；预后

    Three dimensional-conformal radiotherapy combined with TP regimen treated for inoperable ⅢAN2 non-small cell lung cancer

    NIE Xue-cheng,CHONG Dao-qun,GUAN Yu-mei.Department of Oncology,The First People’s Hospital of Jining,Shandong 272111,China

    【Abstract】 Objective To evaluate the acute side effects and efficacy of three dimensional-conformal radiotherapy combined with TP regimen treated for inoperable ⅢAN2 non-small cell lung cancer.Methods 64 patients with inoperable ⅢAN2 non-small cell lung cancer were treated with three dimensional-conformal radiotherapy combined with (group 1) or radiotherapy combined with (group 1).The radiation dose 66 Gy.Paclitaxel 60mg(m2·d) ......