·研究原著·

    关键词: 胰腺炎;炎症介导素类;预后

    摘 要:目的 探讨应用地塞米松抑制炎症过程中多种炎症介质的作用或抑制炎症介质的产生，以期提高重症急性胰腺炎(SAP)的治疗效果. 方法 SAP40例随机分为2组:治疗组和普通组，于治疗后1，3，5，7，10，14d测定外周血6-酮-前列腺素F1 α(6-keto-PGF1 α)、血栓素(TXB2 )、白细胞介质-6(IL-6)的水平并用硝酸还原法测定一氧化氮(NO)水平，每7d CT测定胰腺影像变化，统计并发症发生率、感染中转手术率、平均住院时间. 结果 治疗组6-Keto-PGF1 α，TXB2 ，IL-6，NO较普通组显著下降(P<0.05)，CT示胰腺坏死、胰周渗出在2wk后明显减少，并发症发生率、感染中转手术率明显低于普通组(P<0.05). 结论 应用非特异性炎症介质拮抗剂地塞米松可以显著降低血中炎症介质水平，降低胰腺炎症程度，是治疗SAP的有效药物.

    Improving the prognosis of severe acute pancreatitis by using dexamethasone inhibiting inflammatory mediators

    MA Mao，GENG Zhi-Qin，HE Xin-Yeng，MENG Shao-Qing

    Department of Geriatrics Surgery，First Affiliated Hospital，Xi'an Jiaotong University，Xi'an710061，China

    Keywords:pancreatitis;inflammation mediators;prognosis

    Abstract:AIM To investigate how to improve the prognosis of SAP by using dexamethasone to inhibit the production of in flammatory mediators or by blocking the effects of inflam-matory mediators.METHODS Forty patients with SAP were randomly allocated into two groups:Treatment group and ordinary group.6-Keto-PGF1 α ......