白藜芦醇_____脑缺血；白藜芦醇；明胶酶B；血脑屏障

白藜芦醇对小鼠永久性局灶脑缺血损伤后血脑屏障的影响

http://www.100md.com 《第四军医大学学报》 2006年第2期

白藜芦醇,,脑缺血；白藜芦醇；明胶酶B；血脑屏障,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Influence of resveratrol on damage of blood brain barrier in permanent focal cerebral ischemic injury in mice

    PENG YaBin, ZHANG Xiang, JIANG XiaoFan, GAO DaKuan

    1Department of Neurosurgery ,Third Central Hospital of Chinese PLA, Baoji 721004, China, 2PLA Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To discuss the influence of resveratrol on the damage of blood brain barrier (BBB) in permanent focal cerebral ischemic injury in mice. METHODS: Ischemia was induced by intraluminal permanent middle cerebral artery occlusion(MCAO)and Evans blue was injected. The extent and quantity of Evans blue extravasation were measured and the expression of MMP9 was shown by RTPCR. RESULTS: Resveratrol significantly diminished the extent and quantity of Evans blue extravasation [(101±15)mm3 vs (149±17) mm3, (8.6±2.9)% vs (18.6±3.8)%, P<0.01] and inhibited the expression of MMP9 [(0.693±0.008) vs (1.537±0.037), P<0.01]. CONCLUSION: Resveratrol, due to its neuroprotective effect, can inhibit the activity of MMP9 and alleviate the disruption of BBB. ......

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