Development of GZY therapeutic instrument for osteoporosis

    LUO Erª²Ping£¬JIAO Liª²Cheng£¬SHEN Guangª²Hao£¬WU Xiaoª²Ming£¬XIE Kangª²Ning, LU Liª²Hua£¬XU Qiaoª²Ling

    1Research Center of Intelligent Information Processing, School of Electronic Engineering, Xidian University, Xi¬ðan 710071, China, 2Department of Military Medical Equipment & Metrology, School of Biomedical Engineering, 3Department of Chemistry, School of Pharmacy, 4School of Nursing, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To develop a GZY therapeutic instrument for osteoporosis and to evaluate the curative effect. METHODS: By the mechanism analysis of athermal biological effects on low intensity pulsed magnetic fields and the theory of calculating the uniformity of output magnetic fields, a new method of gaining more homogeneous magnetic fields was proposed. To evaluate the curative effect, 20 experimental female SD rat models of osteoporosis were established by ovariectomy. The animal models were randomly divided into 2 groups(n=10, per group): experimental group treated with GZY instrument and control group not exposed to magnetic fields. The two groups were raised in the same conditions. After 8 weeks, the changes of serum osteocalcin, bone mineral density and histomorphometry were examined. RESULTS: ¢Ù The output uniform region of GZY instrument was larger than that of Helmholtz coils. ¢Ú Compared with those of control group, the values of experimental group such as BMD, trabecular area, trabecular thickness and trabecular number significantly increased[(0.331¡À0.006 vs 0.266¡À0.009) g/cm2, (36.1¡À1.7 vs 25.0¡À1.8)%, (70¡À5 vs 48¡À3) ¦Ìm, (6.9¡À0.1 vs 4.1¡À0.2) #/mm, P<0.05] but the values of trabecular separation and serum osteocalcin decreased obviously[(139¡À9 vs 166¡À11) ¦Ìm, (1.41¡À0.10 vs 2.61¡À0.09) ¦Ìg/L, P<0.05]. CONCLUSION: GZY instrument can improve the general level of experiments. It is helpful for the treatment and prevention of osteoporosis. ......