抗AT1和α1受体自身抗体与高血压病合并肾损害的关系
抗AT1,,高血压,并发症;肾功能衰竭;受体;自身抗体,0引言,1对象和方法,2结果,3讨论,【参考文献】
Relationship between autoantibodies against AT1 and α1 receptors and hypertension with renal failureZHAO LinShuang, LIAO YuHua, WANG Min, ZHOU ZiHua, XIANG GuangDa,HOU Jie, YUE Ling, XU Lin
1Department of Endocrinology, Wuhan General Hospital, Guangzhou Military Area Command, Wuhan 430070, China, 2Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
【Abstract】 AIM: To study the role of the autoantibodies against angiotensin Ⅱtype 1 receptor (AT1 receptor) and α1adrenergic receptor(α1 receptor) in the development of hypertension combined with renal failure. METHODS: The epitopes of the second extracellular loop of AT1 receptor (165-191) and α1 receptor (192-218) were synthesized and used respectively to screen sera autoantibodies from patients with hypertension and renal failure (n=61), patients with hypertension but without renal failure (n=60) and healthy blood donors (n=40, control) by ELISA and to screen the hormones of nerve and endocrine by RIA and by FIA. RESULTS: The positive rates of the autoantibodies against AT1 receptor (59.0%)and α1 receptor (54.1%) in patients with hypertension and renal failure were higher than those in patients with hypertension but without renal failure (13.3% and 10.0% respectively) (P<0.01) and they were also higher than those of healthy donors (10.0% and 7.5% respectively) (P<0.01). The hormones of nerve and endocrine (PRA, AngⅡ, ALD, E, NE) in patients with hypertension and renal failure were higher than those of patients with hypertension but without renal failure and they were also higher than those in healthy donors (P<0.05, P<0.01). CONCLUSION: Autoantibodies against AT1 receptor and α1 receptor may play some important roles in the pathogenesis of the hypertension combined with renal failure and activate accordingly the hormones of nerve and endocrine system in patients with the disease. ......
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