关键词: 心房颤动;导管消融术;心包

    摘 要:目的 研究心房单线消融对乙酰胆碱加心房突然刺激诱发的犬心房纤颤的治疗效果. 方法 选用10只犬，以持续静注乙酰胆碱加心房突然刺激诱发持续性房颤(≥1min)，观察心房单线消融前后房颤诱发率、持续时间、血流动力学和电生理指标的变化. 结果 所有犬均能通过持续静注乙酰胆碱加心房突然刺激诱发出持续性房颤，房颤诱发率92%，平均持续时间为(204±117)s，经心房单线消融部分隔离心房刺激位点后，持续性房颤诱发率为8%，平均持续时间6s(中位数)，与消融前比较有明显差异(P<0.01).而消融前后最大心率、校正窦房结恢复时间及血流动力学指标、左室内压、左室最大收缩速率、左室最大舒张速率均无明显变化. 结论 在此种房颤模型上，以心房单线消融部分隔离刺激位点可以起到抑制房颤诱发的作用，消融后血流动力学及电生理指标无明显变化，该方法具有损伤小和安全性高的特点.

    Research of simple linear atrial ablation in eliminat┐ing sustained atrial fibrillation in dogs

    YANG Zhao-Xu CAI Zhen-Jie WANG Yue-Min ZHANG Xiao-Dong YU Shi-Qiang ZHOU Geng-Xu CHENG Yun-Ge

    1 Department of Cardiovascular Surgery，Xijing Hos-pital，

    2 Department of Physiology，Faculty of Pre-clinical Medicine，Fourth Military Medical Universi-ty，Xi'an710033，China

    Keywords:atrial fibrillation;catheter ablation;epicardium

    Abstract:AIM To study the effect of simple linear atrial ablation on eliminating canine sustained atrial fibrillation(AF)iduced by IV infusion of acetylcholine and atrial burst-pacing.METHODS Sustained AF(≥1min)was induced by IV infusion of acetylcholine and atrial burst-pacing in10dogs to investigate the inducibility and duration of AF ......