关键词: 加速度;推拉动作;推拉效应;记忆;行为;大鼠

    摘 要:目的 探讨推拉动作后再高G值暴露对大鼠记忆功能和行为的影响. 方法 24只雄性SD大鼠随机分为对照组、+10Gz/3min组和推拉组3组，每组8只.记录+Gz暴露后不同时间大鼠记忆功能和行为的变化. 结果 推拉组大鼠正确反应率在暴露后即刻与2d时较对照组显著降低(P<0.01)，反应时在暴露后即刻、2d及4d时较对照组及+10Gz/3min组显著延长(P<0.01)，错误数及错误时间在暴露后6h及6d时较对照组及+10Gz/3min组显著增加(P<0.01)，潜伏期在暴露后6h，2d，4d及6d时较对照组及+10Gz/3min组显著缩短(P<0.01)，理毛次数在暴露后6h时与对照组相比显著减少(P<0.05)，中央格内停留时间在暴露后即刻与对照组及+10Gz/3min组相比显著延长(P<0.01)，平衡能力在暴露后即刻及2d时较对照组和+10Gz/3min组显著降低(P<0.01). 结论 推拉动作后再进行+10Gz/3min暴露可导致大鼠严重的持续性记忆功能障碍和平衡失调.

    Effect of push┐pull maneuver on rat's memory and behavior

    WEI Ying-Bo，SUN Xi-Qing，CAO Xin-Sheng，YAO Yong-Jie

    Department of Aerospace Biodynamics，Faculty of Aerospace Aviation Medicine，Fourth Military Medi-cal University，Xi'an710033，China

    Keywords:acceleration;push-pull maneuver;push-pull ef-fect;memory;behavior;rats

    Abstract:AIM To explore the effect of push-pull maneuver on rat's memory and behavior.METHODS Twenty-four male SD rats were randomly divided into three groups:the control group，the push-pull and the+10Gz/3min groups.The changes in rat's memory and behavior were measured af-ter+Gz exposure.RESULTS As compared with the con-trol ......