关键词: 皮肤;培养;移植;免疫排斥

    摘 要:目的 检测组织工程皮肤的生物活性及免疫原性，探讨临床可行性. 方法 以新生SD大鼠皮肤为原材料培养组织工程复合皮肤并将其移植到成年Wistar大鼠，通过大体观察、组织学检测对不同时间自体、异体及组织工程复合皮肤移植进行比较，研究了组织工程复合皮肤的存活及免疫排斥情况. 结果 异体皮肤移植组有明显的免疫排斥，组织工程皮肤组未见有明显排斥，且与自体皮肤结合良好. 结论 组织工程复合皮无明显的免疫排斥，是较好的皮肤移植替代品，具有潜在的发展前景.

    Composite tissue engineering skin allograft to rapair rat skin defection

    LIU Xiao-Liang JIN Yan NIE Xin LIU Yuan LU Hong-Bing ZHAO Yu WANG Jun-Lin Tipoe GL

    1 Department of Pathology，Stomatological College，Fourth Military Medical University，Xi'an710033，China，

    2 Department of Anatomy，Faculty of Medicine，The University of Hong Kong

    Keywords:skin;culture;graft;immunorejection

    Abstract:AIM To observe the immunogenicity and bioac-tivity of tissue engineering skin and to determine its possibili-ty on clinic.METHODS The tissue engineering skin which drew the materials from neonatal SD rats was cultured，and then grafted to adult Wistar rats to be compared with rats au-tograft and allograft through observing their developments and histological determinations.RESULTS The allograft skin showed significant rejection ......