【摘要】 目的 探求女性乳腺癌的危险因素，为乳腺癌的防治提供依据。 方法 采用病例对照研究方法，问卷调查2003年1月～2005年4月入院的经病理组织学确诊的女性乳腺癌生存病例及同时段入院的外伤患者。利用SPSS进行数据录入和分析，用logistic回归模型进行单因素和多因素分析筛选出有意义的危险因素。 结果 经单因素及多因素分析，与乳腺癌发病有关的因素为:月经经期不规则、行经期长、流产史、青霉素过敏史等，月经初潮晚能降低乳腺癌的发病风险。 结论 月经经期不规则、行经期长、流产史及青霉素过敏史等是乳腺癌危险因素，而月经初潮晚对乳腺癌有保护作用。

    【关键词】 乳腺肿瘤;危险因素;病例对照研究

    A case-control study on risk factors of female breast cancer

    LI Xue-lian，HE Miao，XU Zhi-yuan，DAI Xiao-chun ，GONG Wei ，LI Ni ，ZHOU Bao-sen

    1.Department of Epidemiology，China Medical University，Shenyang 110001，China;2.Computer Office in The First Affiliated Hospital of China Medical University，Shenyang 110001，China;3.Cancer Institute of The First Affiliated

    Hospital of China Medical University，Shenyang 110001，China

    【Abstract】 Objective A case control study was conducted to explore risk factors of female breast can-cer.Methods Total500female survivors with breast cancer were surveyed，matched with trauma con-trols in hospital at the same time.SPSS2000was used to code and enter the data.Univariate and multi-variate logistic regression analysis were performed for screening the significant risk factors of breast can-cer.Results Univariate and multivariate logistic regression analysis indicated that long paramenstrum ......