【摘要】 目的 了解发生乙型肝炎病毒宫内感染的新生儿的转归情况，并探讨影响新生儿乙型肝炎病毒宫内感染的相关因素。 方法 对HBsAg阳性母亲及新生儿进行随访。应用酶联免疫吸附试验双抗夹心法检测HBsAg阳性孕妇及其新生儿血清乙型肝炎病毒标志物，采用聚合酶链反应技术检测血清乙型肝炎病毒DNA。分析比较新生儿宫内感染组和非宫内感染组的差异，并对母亲HBeAg阳性与宫内感染新生儿乙型肝炎病毒慢性化的关系进行分析。 结果 随访到214对HB-sAg阳性母亲及其新生儿，有10例新生儿发生宫内感染，其中2例发生乙型肝炎病毒慢性感染。母亲既往HBsAg和HBeAg双阳性、母亲既往乙型肝炎病毒DNA阳性在新生儿宫内感染组和非宫内感染组中的分布差异有显著性(χ 2 值分别为6.68和14.80，P<0.05)。母亲既往HBeAg阳性在新生儿乙型肝炎病毒慢性感染组和非乙型肝炎病毒慢性感染组中的分布差异有显著性。 结论 母亲既往HBsAg和HBeAg双阳性、既往乙型肝炎病毒DNA阳性可能导致新生儿宫内感染危险增加，母亲既往HBeAg阳性可能导致新生儿乙型肝炎病毒慢性感染。

    【关键词】 肝炎病毒，乙型;疾病传播，垂直;危险因素

    A follow-up study on influence factors of newborn infants with hepatitis B virus intrauterine infection

    XU Yuan-yong，MEN Ke，SHAO Zhong-jun，XU Jian-qiu，CUI Heng-chun，LI Duan，YAN Yong-ping 1 ，XU De-zhong.

    1.Department of Epidemiology，Fourth Military Medical University，Xi'an 710032，China;2.Department of Obstetrics，Maternal and Children Hospital of Shaan Province，Xi'an 710003，China

    【Abstract】 Objective To observe the development of infants with Hepatitis B virus intrauterine infec-tion and to study correlation factors of infants with Hepatitis B virus intrauterine infection.Methods Correlation factors between infection group and non-infection group were analysed and compared total214mother with HBsAg positive and their infants were follow-up investigated respectively.HBV marker of all subjects were detected by enzyme-linked immunosorbent assay ......