[摘要] 目的 分析晚期非小细胞肺癌(NSCLC)预后相关因子，以判断病情、指导治疗。方法 将107例NSCLC患者按中医辨证分型分为5型，部分患者采用中医药方法治疗，部分患者采用中西医结合方法治疗。采用卡卜兰-迈尔(Kaplan-Meier)方法进行生存分析，采用Cox回归分析进行晚期NSCLC的预后分析。结果 5种中医分型的生存时间气虚痰湿型>气滞血瘀型>阴虚毒热型>气阴两虚型>热毒炽盛型，各中医证型的生存率相比较均具有显著性差异(P均<0.01)。中西医结合治疗比纯中医药治疗疗效好(P<0.05)。结论 晚期NSCLC预后保护因子有治疗方法、CD 4+ 、CD 4+ /CD 8+ 、卡氏评分、辨证分型、疗程，预后危险因子有原发病灶、年龄、吸烟、CD 8+ 、恶性胸水、上腔静脉综合征、脑转移、骨转移、临床分期、病理类型、TPA、CEA、CA125。

    [关键词] 非小细胞肺癌;晚期预后因子;危险因子;保护因子

    Prognosis factors analysis of nonsmall-cell lung cancer in advanced stage

    ZHANG Shu-xiang

    (The First Affiliated Hospital of Henan Traditional Chinese Medical College，Zhengzhou450000，Henan，China)

    Abstract:Objective It is to analyze the prognosis correlated factors of nonsmall-cell lung cancer(NCSLC)in advanced stage so to diagnose the disease and guide treatment.Methods107patients with NCSLC were divided into five types of syn-dromes according to differential diagnosis typing.Some patients were treated with traditional Chinese medicine and some were treated with methods of integrated traditional Chinese and western medicine.Existence analysis was done with Kaplan-Meier method and prognosis analysis of NCSLC in advanced stage was done with Cox regression statistical method.Results Five syndromes survival time from long to short in sequence was Qi-deficiency plus phlegm and wetness syndrome>Qi stag-nancy and blood stasis syndrome>Yin-dificiency plus toxic heat syndrome>Qi-Yin deficiency syndrome>pyretic toxicity fervidity syndrome.There were significant difference in survival rate among five syndromes(P<0.01).The curative effect of integrated traditional Chinese and western medicine was better than simple traditional Chinese medicine(P<0.05).Con-clusion The prognosis protective factors of NSCLC in advanced stage were treatment method ......