【摘要】 目的 对肥厚型非梗阻性心肌病的病史、有关症状及客观检查等进行综合分析，以判断其预后。方法 通过病史、Holter监测、心电图及多普勒超声心动图等筛选，对3代人进行全面检查。结果 6例肥厚型心肌病患者，男4例，女2例，年龄21～82岁，平均(48±23)岁，3例主诉时有胸闷心悸不适，多普勒超声心动图示不对称性室间隔肥厚(13～21mm )。5例前中室间隔肥厚，1例后室间隔肥厚，心电图示2例类似心肌梗死图形，标准导联Ⅱ、Ⅲ、avF、Ⅴ5～Ⅴ9导联异常Q波，2例Holter监测示短阵室性心动过速。结论 肥厚型非梗阻性心肌病症状可变化多端，大多数症状不明显，年轻时发病的患者甚至晚年才被诊断，对老年有心律失常患者，每年需定期随访。患者耐受性好，一般预后较好，不影响其预期寿命。

    【关键词】 心电图；超声心动图；肥厚型心肌病

    Familial hypertrophic cardiomyopathy

    GU Yi-min,REN Jian-ying,ZHOU Min,et al.

    Department of Cardiology,Xuhui District Central Hospital,Shanghai 200031,China

    【Abstract】 Objective In order to judge the prognosis of hypertrophic cardiomyopathy(HCM),there was an analysis of clinical history made related to symptoms and physical examinations.Methods 3 generations in one family were surveyed through the screening of history,electrocardiogram,Holter monitoring and doppler echocardiogram.Results 6 patients suffered from HCM,aged(48±23) (21～82 years old),2 of the 6 patients sometimes complained of shortness of breath.Doppler echocardiogram showed ventricalar septal of asymmetrical hypertrophy.Among them,5 had anterior-middle ventricular septal hypertrophy and 1 had posterior ventricular septal hypertrophy(13～21mm).Electrocardiogram showed sinus rhythm,non-specific ST-T changes.There were abnomal Q wave in lead Ⅱ、Ⅲ、avF、Ⅴ5～Ⅴ9 in 2 cases,which were similar to myocardial infarction.Short paroxysmal ventricalar tachycardia was seen by holter monitoring in 2 cases.Conclusion The symptoms are varied.The patients may tolerate well without any manifestations until late stages.The symptoms of arrhythmias especially ventricalar tachycardia in young adults may have a sudden catastrophe.It is a good suggestion that the follow-up should be carried out every year.The prognosis of HCM usually has a normal life espectancy. ......