胃癌证型与肿瘤增殖的关系
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施 俊, 魏品康, 许 玲, 何 金, 孙大志
中医证型;增殖;Ki67;CyclinE,施俊,魏品康,许玲,孙大志,何金,施俊,Relationshipbetweengastriccarcinomatraditio
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施俊, 魏品康, 许玲, 孙大志, 第二军医大学长征医院中医科 上海市 200003
何金, 第二军医大学长征医院病理科 上海市 200003
施俊, 2005年第二军医大学硕士, 讲师, 主要从事中西医结合消化道肿瘤的防治研究.
通讯作者: 魏品康, 200003, 上海市凤阳路415号, 第二军医大学长征医院中医科. czzyk@smmu.edu.cn
电话: 021-63610109-73188 传真:021-63520020
收稿日期: 2006-01-15 接受日期: 2006-02-21
Relationship between gastric carcinoma traditional Chinese medicine classifications of syndrome and tumor proliferation
Jun Shi, Pin-Kang Wei, Ling Xu, Jin He, Da-Zhi Sun
Jun Shi, Pin-Kang Wei, Ling Xu, Da-zhi Sun, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China
Jin He, Department of Pathology, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China
Correspondence to: Dr. Pin-Kang Wei, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. czzyk@smmu.edu.cn
Received: 2006-01-15 Accepted: 2006-02-21
Abstract
AIM: To study the relationship between gastric carcinoma traditional Chinese medicine (TCM) classifications of syndrome and tumor proliferation.
METHODS: Ninety-one patients with gastric carcinoma were assigned into 6 groups according to TCM classification of syndrome criteria before operation. Specimens prepared from operation were detected for Ki67 and Cyclin E protein expression by EnVision method of immunohistochemistry.
RESULTS: The positive rates of Ki67 and Cyclin E expression were 98.90% (90/91) and 72.53% (66/91), respectively, in gastric carcinoma. The expression of Cyclin E protein was correlated with the histological types (P = 0.039 4) and distant metastasis (P = 0.009 6). There was significantly positive relationship between Cyclin E protein expression and distant metastasis in female patients (P = 0 ......
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