慢性丙型肝炎患者血清HCV RNA, ALT与肝脏病理间的关系
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李 颖, 丁 洋, 王雪莲, 刘 沛
丙型肝炎病毒;RNA;丙氨酸氨基转移酶;组织病理学,慢性丙型肝炎患者血清HCVRNA,ALT与肝脏病理间的关系,李颖,丁洋,王雪莲,刘沛,CorrelationsofserumhepatitisCv
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李颖, 丁洋, 王雪莲, 刘沛, 中国医科大学附属第二医院感染科 辽宁省沈阳市 110004
辽宁省医学科技创新工程技术项目(辽财企), No. [2004]302
通讯作者: 刘沛, 110004, 沈阳市和平区三好街36号, 中国医科大学附属第二医院感染科. syliupei2003@yahoo.com.cn
电话: 024-83956451 传真: 024-83956451
收稿日期: 2006-01-20 接受日期: 2006-01-26
Correlations of serum hepatitis C virus RNA and alanine transaminase with liver histopathological changes in patients with chronic hepatitis C
Ying Li, Yang Ding, Xue-Lian Wang, Pei Liu
Ying Li, Yang Ding, Xue-Lian Wang, Pei Liu, Department of Infectious Diseases, the Second Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Supported by the Medical Science and Technology Innovation Project of Liaoning Province, No. [2004]302
Correspondence to: Pei Liu, Department of Infectious Diseases, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. syliupei2003@yahoo.com.cn
Received: 2006-01-20 Accepted: 2006-01-26
Abstract
AIM: To investigate the relationship among serum hepatitis C virus RNA titer, alanine trans-aminase (ALT) and liver histological changes in patients with chronic hepatitis C.
METHODS: Fluorescent quantitative polymerase chain reaction was used to detect the level of serum HCV RNA in 132 patients with chronic hepatitis C; meanwhile, the levels of serum ALT were measured by biochemical instrument. Liver biopsy was performed in 30 of 132 patients, and histopathological changes were observed by HE staining under light microscope and scored according to the grades of liver necro-inflammatory activity and stages of liver fibrosis.
RESULTS: Of 132 cases, 98 (74.2%) were positive for HCV RNA (over 1.0×106 copies/L), and 99 (75.0%) were with a higher ALT level. No significant correlation was noted between HCV RNA titer and ALT level (r = 0.40, P = 0.695), but a statistical relationship was noted between HCV RNA titer and the abnormal rate of ALT level (r = 1 ......
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