TGF-α和EGFR在Barrett食管和食管腺癌的表达
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呼闯营, 贺彩峰
转化生长因子α;表皮生长因子受体;Barrett食管;食管腺癌,呼闯营,贺彩峰,呼闯营,Expressionoftransformingg
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呼闯营, 贺彩峰, 苏州大学附属第二医院消化科 江苏省苏州市 215004
呼闯营, 2005年华中科技大学同济医学院博士毕业, 讲师, 主要从事消化道肿瘤的研究.
通讯作者: 呼闯营, 215004, 江苏省苏州市三香路1055号, 苏州大学附属第二医院消化科. huchuangying@163.com
电话: 0512-68631229 传真: 0512-68284303
收稿日期: 2006-02-14 接受日期: 2006-03-06
Expression of transforming growth factor alpha and epidermal growth factor receptor in Barrett’s esophagus and esophageal adenocarcinoma
Chuang-Ying Hu, Cai-Feng He
Chuang-Ying Hu, Cai-Feng He, Department of Gastroenterology, the Second Affiliated Hospital of Suzhou University, Suzhou 215004, Jiangsu Province, China
Correspondence to: Dr. Chuang-Ying Hu, Department of Gastroenterology, the Second Affiliated Hospital of Suzhou University, 1055 Sanxiang Avenue, Suzhou 215004, Jiangsu Province, China. huchuangying@163.com
Received: 2006-02-14 Accepted: 2006-03-06
Abstract
AIM: To investigate the expression of transform-ing growth factor alpha (TGF-α) and epidermal growth factor receptor (EGFR) in Barrett’s esophagus and esophageal adenocarcinoma.
METHODS: Immunohistochemistry (SABC assay) was used to detect the expression of TGF-α and EGFR protein in patients with reflux esophagitis (n = 13), Barrett’s esophagus (n = 17), esophageal adenocarcinoma (n = 11) and normal esophageal mucosa (n = 30).
RESULTS: In the development of reflux esophagitis, Barrett’s esophagus and esophageal adenocarcinoma, the expression of TGF-α and EGFR protein increased gradually and closely correlated with each other (r = 0.951, P < 0.01). TGF-α protein was mainly expressed in the cytoplasm. EGFR was expressed in the cellular membrane in the normal esophageal mucosa and reflux esophagitis, but strongly positively expression was also observed in the cytoplasm and nucleus of cells in Barrett’s esophagus with dysplasia and esophageal adenocarcinoma.
CONCLUSION: TGF-α and EGFR expression increase and may play synergic roles in the development of Barrett’s esophagus and esophageal adenocarcinoma ......
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