壳聚糖体外抗幽门螺杆菌的作用及其影响因素
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郑铁生, 王亚娜, 宗爱萍
壳聚糖;幽门螺杆菌;抑菌作用,郑铁生,王亚娜,通讯作者:,InvitroactionofchitosanagainstHelicobacterpylori
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郑铁生, 江苏大学医学技术学院 江苏省镇江市 212001
王亚娜, 宗爱萍, 镇江科力生物技术有限公司 江苏省镇江市 212001
高校基金资助项目, No. 2291270004
通讯作者: 郑铁生, 212001, 江苏省镇江市东吴路2号, 江苏大学医学技术学院. jsdxzts@163.com
电话: 0511-5039779 传真: 0511-4438079
收稿日期: 2006-01-25 接受日期: 2006-02-13
In vitro action of chitosan against Helicobacter pylori and its influential factors
Tie-Sheng Zheng, Ya-Na Wang, Ai-Ping Zong
Tie-Sheng Zheng, College of Medical Science Technology, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
Ya-Na Wang, Ai-Ping Zong, Zhenjiang Koly Biology-Technology Cooperation Limited, Zhenjiang 212001, Jiangsu Province, China
Supported by the Fund for Higher Education, No. 2291270004
Correspondence to: Tie-Sheng Zheng, College of Medical Science Technology, Jiangsu University, 2 Dongwu Road, Zhenjiang 212001, Jiangsu Province,China. jsdxzts@163.com
Received: 2006-01-25 Accepted: 2006-02-13
Abstract
AIM: To investigate the in vitro action of the chitosans against Helicobacter pylori and its influential factor.
METHODS: Stiletto method was used to examine the inhibitory effect of chitosans at different concentrations and pH values on three strains of H pylori, including SSI and two other strains isolated from patients. Bacteriostatic test was performed to explore the molecular weight and metal ion on the bacteriostatic activity of chitosans against H pylori.
RESULTS: Chitosans had inhibitory effect on all the three kinds of H pylori strains, and the effects were not significantly different between the three strains (P > 0.05). Within the scopes of pH8.5-5.5, the action of chitosan on H pylori strengthened with the lowering of the pH value (P < 0.01). Chitosans at different concentrations had marked difference in suppressing H pylori (P < 0.01), and the action reached the peak when it is at 40 g/L. As the chitosans weighted less than 400 000 u, the bacteriostatic activity increased first and then decreased, and the chitosan weighing 10-200 000 u had the strongest action, lasting 134 h ......
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