中药泻心汤对大鼠胃排空和胃肠激素的影响
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刘晓霓, 牛 欣, 司银楚, 金秀东
胃排空;胃肠激素;泻心汤刘晓霓,牛欣,司银楚,金秀东.中药泻心汤对大鼠胃排空和胃肠激素的影响.世界华人消化杂志2006;14(10)997-1000 三方药味配比(g)1.2方法60只大鼠
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刘晓霓, 金秀东, 牡丹江医学院生理教研室 牡丹江市 157011
牛欣, 北京中医药大学生理教研室 北京市 100029
司银楚, 北京中医药大学解剖教研室 北京市 100029
通讯作者: 刘晓霓, 157011, 牡丹江市通乡路3号, 牡丹江医学院生理教研室. lxnlxm@126.com
电话: 010-6582156-3384
收稿日期: 2006-02-06 接受日期: 2006-03-13
Influence of Xiexin decoction on gastric emptying and gastrointestinal hormones in rats
Xiao-Ni Liu, Xin Niu, Yin-Chu Si, Xiu-Dong Jin
Xiao-Ni Liu, Xiu-Dong Jin, Department of Physiology, Mudanjiang Medical College, Mudanjing 157011, Heilongjiang Province, China
Xin Niu, Department of Physiology, Beijing University of Traditional Chinese Medicine, Beijing 100029, China
Yin-Chu Si, Department of Anatomy, Beijing University of Traditional Chinese Medicine, Beijing 100029, China
Correspondence to: Xiao-Ni Liu, Department of Physiology, Mudanjiang Medical College, 3 Tongxiang Road, Mudanjing 157011, Heilongjiang Province, China. lxnlxm@126.com
Received: 2006-02-06 Accepted: 2006-03-13
Abstract
AIM: To observe the effect of Banxia (BX), Shengjiang (SJ) and Gancao (GC) Xiexin decoction on the gastric evacuation and secretion of gastrointestinal hormones.
METHODS: Sixty rats were randomly and averagely divided into control group, BX, SJ and GC group. The rats in BX, SJ, and GC group were treated with the decoctions of BX, SJ, and GC respectively [5.67, 7.42, 5.36 g/(kg•d)]. Gastric residue was observed in all the rats with a marker of dextran blue-2000 to determine the capacity of gastric emptying. The levels of gastrointestinal hormones, including vasoactive intestinal peptide (VIP), substance P (SP), somatostatin (SS), gastrin (GAS), and motilin (MTL), in rat blood were measured by radioimmunoassay.
RESULTS: In comparison with that in the normal controls (99.9% ± 32.2%), gastric residue decreased significantly in BX group (66.1% ± 21.1%, P = 0.014) and increased significantly in SJ group (141 ......
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