【摘要】 目的 了解子宫内膜异位症(内异症)患者服用小剂量米非司酮(含株停)治疗3个月后内膜组织及血清中雌激素的变化及临床效果。方法 分别采取用药前后及对照组血清、在位、异位内膜组织匀浆后的上清液，通过发光免疫法测定血清及内膜中雌二醇(E2)。结果 内异症未用药组的在位、异位内膜增生期E2差异无显著性(P>0.05),在位、异位内膜与对照组无论增生期、分泌期差异均有显著性(P<0.05)。在位内膜与对照组内膜有增生与分泌周期性改变。未用药组与用药组血清及内膜组织中E2比,差异均有显著性(P<0.05)。未用药组与对照组血清中E2差异无显著性(P>0.05)，而且二组均有周期性变化。对照组内膜E2与血清中E2有相关性r=0.652. 而内异症用药前后内膜E2均与血清E2无相关性r=0.190。结论 米非司酮能通过降低内异症患者内膜组织及血清中E2水平而达到控制临床症状及疾病的发展，但其作用途径可能不相同。

    【关键词】 子宫内膜异位症; 内膜; 血清; 雌激素; 放射免疫法

    Effect of mifepristone on the level of estradiol in eutopic 、ectopic and serum of endometriosis

    ZHAO Xuan，CHEN Shi-rong, WU Hua-zhen,et al.

    Department of Obstetrics and Gynecology of the First Affiliated Hospital of Zunyi Medical College, Zunyi,Guizhou Province, 563003,China

    【Abstract】 Objective To learn the clinical efficacy of low-dose mifepriston orally for 3 months and the changes of estradiol(E2)level in eutopic 、ectopic and serum of endometriosis patients. Methods Before and after treatment ,the level of E2 in serum and endometrial tissue homgenate of eutopic and ectopic endometrium of endometriosis and the control group were measured by radioimmunoassay. Results There were no significant diffrence of E2 was found between the eutopic group and the ectopic group after endometriosis was treated (P>0.05). But significants of endometrium were occurred in two groups both in proliferative stage and progestational stage (P<0.05) ,and the variations of endometrium in two stages were observed both in the eutopic and the control group (P<0.05) .Furthermore,periodic changes of serum E were observed but no significant difference existed between the non-medicated group and the control group (P>0.05). On the contrary the difference of E2 in endometrium was significance. Correlations of E2 among endometrium and serum were then calculated in control group, and its correlated ratio was 0.625,but no similar correlations of E2 were founded in endometriosis pre-and post-treatment( r=0.190). Conclusion Mifepristone can reduce the level of estradiol in endometrium and in serum of endometriosis, thus controling the clinical symtom and development, but its mechanism may be different. ......