【摘要】 目的 探讨Meige综合征的临床特点、诊断和治疗。方法 回顾性分析65例Meige综合征患者的临床资料，并进行总结。结果 男女患病比率为1:1.83，40岁以上发病53例，受累部位依次为眼睑58例(89.2%)、口-下颌46例(70.8%)、颈部17例(26.2%)；首发症状以眼部不适、眼睑痉挛最多(42例,占64.6%)，口-下颌肌张力障碍次之(17例,占26.2%)；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。结论 Meige综合征好发于中老年人，女性多见，肌张力障碍最常发生于眼睑，其次为口-下颌、颈部，头MRI有辅助诊断价值，肉毒毒素局部注射较单纯口服药物疗效好。

    【关键词】 Meige综合征；诊断；治疗

    Clinical analysis of 65 Meige syndrome patients

    CHEN Rong-jie,MA Ai-jun,ZHANG Ben-shu.

    Department of Neurology, Huanhu Hospital,Tianjin 300060,China

    【Abstract】 Objective To discuss the clinical characteristics, diagnosis and treatment of Meige syndrome.Methods The clinical materials of 65 patients suffering from Meige syndrome were analyzed retrospectively.Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect. Conclusion Meige syndrome are found more often in female seniors. Myodystonia is likely to involve eyelid, mandibula and neck. Cranial MRI is of diagnostic significance to some extent. Botulinum injection is more effective than oral drugs. ......