【摘要】 目的 评价左旋氨氯地平与厄贝沙坦在高血压病患者早期肾保护作用方面的疗效。方法 入选高血压病1级、2级患者71例，随机分为两组：左旋氨氯地平组(n=35)：口服左旋氨氯地平2.5mg/d；厄贝沙坦组(n=36)：口服厄贝沙坦150mg/d。观察12个月，治疗前、治疗后分别检测肾小球滤过率(GFR)、α-微球蛋白(α-MG)及血压。结果 (1)左旋氨氯地平组和厄贝沙坦组在治疗后GFR均升高；厄贝沙坦组的疗效优于左旋氨氯地平组(P<0.01)。(2)左旋氨氯地平组和厄贝沙坦组在治疗后对α-微球蛋白的降低均有统计学差异，厄贝沙坦组的疗效优于左旋氨氯地平组(P<0.01)。(3)两组在用药后收缩压、舒张压均达到目标值(P<0.01)。两组疗效无统计学差异。结论 左旋氨氯地平和厄贝沙坦在有效降压的同时，使α-微球蛋白降低，使GFR升高；厄贝沙坦的作用优于左旋氨氯地平。它们对高血压病早期肾功能有保护作用。

    【关键词】 高血压；左旋氨氯地平；厄贝沙坦；肾小球滤过率；α-微球蛋白

    Effects of levoamlodipine and irbesartan on the kidney function in patients with early essential hypertension

    CHEN Hai-sheng，LIU Zhuo-min.Datong City Fifth Hospital，Datong 037006，China

    【Abstract】 Objective To investigate the renal protective effects of levoamlodipine and irbesartan in patients with early essential hypertension.Methods 71 patients with hypertension grades 1 or 2 were allocated randomly to 2 groups to receive levoamlodipine 2.5mg(n=35) or irbesartan 150 mg(n=36) once a day. The GFR and α-microglobulin and blood presure were measured before treatment and after treatment.Results (1)GFR increased significantly after treatment in the levoamlodipine group and irbesartan group ......