【摘要】 目的 通过超声心动图检查，观察肢端肥大症患者心脏结构和功能的改变，以及出现高血压并发症后对心脏的影响。方法 研究对象为56例确诊为肢端肥大症的患者，其中17例合并高血压，定为亚组病例。对照组34例。两组均行超声心动图检查，测定心脏结构及功能并对结果进行分析。结果 (1)患病组心肌重量(LVM)及心肌重量指数(LVMi)较对照组明显增加，LVMi达到左室肥厚(LVH)的比例为46.7%，高血压亚组增高更为明显；(2)反映心脏收缩功能的参数射血分数(EF)两组比较，差异无显著性；(3)反映心脏舒张功能的参数左室等容舒张时间(IRT)和二尖瓣减速时间(MDT)，患病组较对照组明显延长，说明心肌松弛性受损。结论 肢端肥大症患者超声心动图表现为明显的心肌肥厚和心肌重量的增加，伴发高血压的患者心肌肥厚有加重的趋势。心脏功能的改变以舒张功能损害为主，反映心肌松弛性减低；而收缩功能则可在较长时间内维持在正常范围。

    【关键词】 肢端肥大症；心脏损害；超声心动图

    Echocardiographic findings in patients with acromegaly

    LI Qun,ZHANG Gui-hong,WANG Jie.Department of Cardilogy,The Affiliated Beijing Tiantan Hospital,Capital University of Medical Science,Beijing 100050,China

    【Abstract】 Objective To observe the cardiac abnormalities in the patients with acromegaly by using echocardiography,and to observe the cardiac damage in patients accompanied with hypertension.Methods 56 patients with acromegaly were involved in this study.Among them 17 patients accompanied with hypertension were denoted as a subgroup.Thirty-four sex and age matched normal individuals were enrolled as control.In order to observe the changes in cardiac structure and function,all patients and controls underwent echocardiographic investigation.Results (1)Left ventricular mass and left ventricular mass index were higher in acromegalics than those in control subjects ......