【摘要】 目的 通过肺针吸细胞病理学检验诊断新技术，探讨肺癌早期诊断及鉴别诊断的价值，进而达到早期诊断肺癌的目的。方法 对112例肺部病变(肿块63例，结节41例，实变8例)进行CT引导下经皮肺穿刺细胞病理学诊断，采用22G穿刺针，精选最佳层面进针多部位取材，活检后行瑞-姬双染色，根据细胞学特征及结构特点及组织学检查，个别病例同时做抗酸染色。结果 穿刺成功率99.1%，在112例中，肺恶性肿瘤74例，穿刺敏感性91.1%，特异性76.9%，假阴性8.9%，良性病变37例，均经手术及随访证实。结论 CT引导下经皮肺细针针吸细胞病理学检验诊断具有创伤小、简单快速、安全可靠、准确率高，符合国情、便于推广，为临床肺癌早期诊断提供重要依据。

    【关键词】 肺癌；针吸细胞学；早期诊断

    Application of cytologic pathology by needle aspiration on early diagnosis of Lung cancer

    SUN Li-ping,WANG Yong-cai,ZHAO Cheng-yan.

    Department of Laboratory,The Second Affiliated Hospital of Dalian Medical University,Liaoning 116033,China

    【Abstract】 Objective Computed tomography (CT) guided fine needle aspiration biopsy (CT guided FNAB) is a new technology of pathological diagnosis. To study new technology of lung cancer diagnosis and differentiation is in early stage, and to achieve the purpose of lung cancer diagnosis and treatment in early stage.Methods Collected 112 specimen of patients(63 specimen of patients were tumor, 41 specimen were tubercle and 8 were solid change) who have lung diseases. Cellular material from these patients by CT-guided FNAB. The aspiration was smeared on glass slides, which were partly air-dried and stained by May-Griinwald and Giemsa, and operate cytological diagnosis and histological diagnosis were made. Specific case examined by acid-fast stain.Results The success rate of CT guided FNAB is 99.1%. And 74 specimen of patients were diagnosed the lung malignant tumour. The puncture sensitivity was 91.1%, speciality rate was 76.9%, and false negative was 8.9%, there were no false positive cases. 37 cases were pathologically benign. All cases were confirmed by surgery and follow-up.Conclusion CT guided FNAB was simple, prompt, safe, dependable and economic, being a safe and moderately invasive diagnostic technique, It is convenient to spread and supplies an important for the carly diagnosis of lung cancer clinically. ......