[摘要]目的 探讨局部性尤文肉瘤的综合治疗效果。 方法 收集经综合治疗的25例尤文肉瘤患者的临床资料，采用Kaplan-Meier法进行分析、Logrank法检验，分析治疗方式和化疗周期对疗效的影响。 结果 综合治疗局部性尤文肉瘤的有效率为92%(23/25)。治疗结束后病灶完全消退组患者的1、3、5年生存率(100%、93.8%和81.3%)明显高于病灶未完全消退组(100%、75.0%和50.0%)(均P<0.05)。行6个周期化疗的患者1、3、5年生存率(100%、93.8%和66.7%)高于3个周期者(88.9%、77.8%和55.6%)(均P<0.01)。局部采用手术或放疗对疗效无明显影响(P>0.05)。 结论 经综合治疗，局部性尤文肉瘤病灶完全消退者生存期明显延长，化疗周期的次数是影响疗效的重要因素。

    [关键词] 局部性尤文肉瘤;放射治疗;化学治疗;手术治疗

    Effects of combined therapy for primary nonmetastatic Ewing's sarcoma

    MA Chao，SUN Xin-chen

    (Department of Orthopaedics，Xuzhou General Hospital，Xuzhou221009，China;Department of Radiotherapy，Affiliated Xuzhou Hospital，Southeast University，Xuzhou221009，China)

    Abstract:Objective To evaluate the efficiency of radiotherapy and operation plus chemotherapy for primary nonmetastatic Ewing's sarcoma.Methods A retrospective analysis was performed on25patients with primary non-metastatic Ewing's sarcoma treated by radiotherapy or operation combined with chemotherapy.Kaplan-Meier analys-is and Logrank test were used to evaluate the survival rates ......