首发念珠菌性外阴阴道炎病原菌与耐药性分析及氟康唑顿服法效果
念珠菌病,,],念珠菌病，外阴阴道炎；微生物敏感性试验；氟康唑,1资料与方法,2结果,3讨论,[参考文献]
[摘要] 目的 研究目前首发念珠菌性外阴阴道炎的病原菌及其对常用药物敏感性，观察氟康唑150 mg顿服对其的治疗效果。方法 对150份首发念珠菌性外阴阴道炎分泌物涂片找假菌丝，同时取分泌物做念珠菌培养及行5氟宝嘧啶、两性霉素、制霉菌素、咪康唑、益康唑、酮康唑、氟康唑药敏试验。并给予氟康唑150 mg顿服后复查临床治疗效果及病原菌培养结果。结果 150份标本培养出念珠菌假菌丝，其中白色念珠菌占96%，光滑念珠菌占2%，热带念珠菌占2%。除2份标本光滑念珠菌对氟康唑耐药外，其余标本对以上所测药物全部敏感。氟康唑150 mg顿服1周后首次复查，痊愈率为91.33%，总有效率为99.33%。结论 首发念珠菌性外阴阴道炎病人白色念珠菌感染占绝大多数，对临床常用抗真菌药物敏感；氟康唑150 mg顿服治疗方便，治愈率高，可作为首发念珠菌性外阴阴道炎的首选治疗方案之一。[关键词] 念珠菌病，外阴阴道炎；微生物敏感性试验；氟康唑
PATHOGEN ANALYSIS OF VULVOVAGINAL CANDIDIASIS AND EFFICACY OF FLUCONAZOLE IN THE TREATMENT OF INITIAL VULVOVAGINAL INFECTION
QI XIUJUAN, MEN JIE, CUI ZHUMEI, et al
(Department of Gynecology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China)
[ABSTRACT]ObjectiveTo analyze the pathogen of vulvovaginal candidiasis and to observe the efficacy of fluconazole in the treatment of initial vulvovaginal candidiasis infection. MethodsOne hundred and fifty patients who were found for the first time with vulvovaginal candidiasis were selected in this study. A microscopic examination and culture of the vaginal discharge were performed to analyze the yeast species. Drug sensitivity tests of pathogens to 5FC, AMB, NYS, MIC, ECO, and KET were done in vitro according to NCCLSs method. All subjects were treated with single dose of Fluconazole (150 mg). The symptoms and side effects were recorded. The culture of the vaginal discharge was repeated one week after the treatment. ResultsCandida albicans, C.tropicalis and C.glabrata were found in 96%, 2% and 2% of te samples, respectively. The sensitivity rates of the microorganisms in vitro to 5FC, AMB, NYS, MIC, ECO, and KET were 100% and the two cases with C. glabrata was not sensitive to Fluconazole. The mycologic cure rate and general efficacy were 91.33% and 99.33% respectively at one week after taking 150 mg of Fluconazole. ConclusionCandida albicans are found in 96% of the patients who suffered from vulvovaginal candidiasis for the first time. Most microorganisms are sensitive to the common anticandias drugs in vitro. The protocol of single dose of 150 mg of Fluconazole 150 mg is safe and effective. ......
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