Effects of Ulinastatin on plasma levels of lipid humoral factors in traumatic hemorrhagic shock in rabbits

    CHEN Tingª²Ting, WANG Gang, GAO Changª²Qing

    Department of Cardiovascular Surgery, General Hospital of Chinese PLA, Beijing 100853, China

    ¡¾Abstract¡¿ AIM: To evaluate the effects of Ulinastatin, a protease inhibitor, on the plasma levels of lipid humoral factors in traumatic hemorrhagic shock. METHODS: Twenty rabbits were randomly divided into two groups: Traumatic hemorrhagic shock group and ulinastatinª²treated group. Blood was sampled at four time points: Preª²shock, postª²shock, as well as 2 h and 4 h after blood volume compensation. The plasma levels of ET, ADM and TXA2, PGI2 were measured. RESULTS: In both two groups, the plasma levels of ET, ADM and TXA2 were significantly higher at the other three observed points than those at preª²shock (P<0.05), while the plasma levels of ET and TXA2 in ulinastatinª²treated group were significantly lower than those in traumatic shock group (P<0.05). CONCLUSION: Ulinastatin has beneficial effects in the treatment of traumatic hemorrhagic shock, possibly by reducing the release of ET and TXA2. ......