摘 要: 目的 了解维生素C注射液(VC)在大鼠急性肺损伤(ALI)中的抗氧自由基作用。 方法 将实验动物随机分为实验和对照各6组，实验组动物用油酸损伤加VC，对照组用生理盐水替换VC。用检测丙二醛(MDA)、超氧化物歧化酶(SOD)、谷光甘肽(GSH)和谷光甘肽过氧化物酶(GSH-Px)来评定氧自由基水平，肺系数评定急性炎症肺水肿程度。取右肺尖组织做光镜病理学切片检查。 结果 VC干预可延缓油酸损伤导致的肺系数最大值，明显降低损伤后MDA水平，升高损伤后SOD、GSH和GSH-Px水平;光镜显示治疗组炎细胞 浸润与肺泡充血水肿程度由重至轻依次为:12 h、24 h、36 h、6 h组。 结论 维生素C是一种较强的抗氧化药物，常规剂量给予即能有效地降低MDA水平，提高SOD、GSH和GSH-Px水平，缓解ALI;给予间隔时间以不超过12 h为宜。

    关 键 词: 维生素C;急性肺损伤;氧自由基

    The influence of Vitamin C to anti-oxygen free radical of ALI on big rats

    CAO Hui-ling， JIANG Yan-xia， L Shi-jie， YANG Ning-jiang， LI Ying-nü， CHEN Mo-ran， ZHONG Yue

    (Jilin Medical College，The Affiliated Hospital， Jilin Medical College， Jilin City， Jilin Province， 132013， Chi- na)

    Abstract: Objective To understand the anti-oxygenic free radicals function of vitamin C (VC) in acute lung injury (ALI) on big rats. Methods The experimental animals were divided into 12 groups randomly. Half were the cura- tive groups and the others were the injured groups as control. The curative groups were injected oleic acid and VC; The VC was replaced by NS in control groups. Assessed the level of oxygen free radicals by examining malondialde- hyde (MDA) ......