尼莫地平____

尼莫地平对戊四氮致癫痫大鼠的抗氧化作用

http://www.100md.com 《齐鲁医学杂志》 2006年第2期

尼莫地平,,],尼莫地平；癫痫；自由基；动物实验；大鼠，Wistar,1材料与方法,2结果,3讨论,[参考文献]

     [摘要] 目的探讨尼莫地平对实验性癫痫鼠的抗氧化作用。方法 50只Wistar大鼠随机分为5组，各10只。正常对照组：腹腔注射生理盐水；癫痫组：腹腔注射戊四氮(PTZ)50 mg/kg, 诱发癫痫后30 min处死；尼莫地平0.1、0.3、0.5 mg/kg 组：腹腔注射PTZ 50 mg/kg前15 min分别注射尼莫地平注射液0.1、0.3、0.5 mg/kg, 每隔24 h重复1次，连续3 d后处死。观察各组大鼠癫痫样发作的潜伏期、持续时间、发作形式，并测定各组大鼠脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)、谷光甘肽过氧化物酶(GSHPX)活性。结果尼莫地平预处理各组大鼠癫痫发作类型以轻型发作为主，发作潜伏期明显延长，持续时间短； SOD活性较癫痫组明显增高，MDA、GSHPX活性明显下降，差异均有显著性(F＝10.720~35.831，P<0.01)。结论尼莫地平可通过抗氧化机制来发挥抗癫痫作用。

    [关键词] 尼莫地平；癫痫；自由基；动物实验；大鼠，Wistar

    ANTIOXIDANT EFFECT OF NIMODIPINE ON RATS WITH EPILEPSY INDUCED BY PENTETRAZOLE

    XIE ANMU，TAN LAN, ZHANG CHEN, et al

    (Department of Neurology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China)

    [ABSTRACT]ObjectiveTo explore the antioxidant role of nimodipine in experimentalepilepsy rats. MethodsFifty Wistar rats were divided into 5 groups: control group, epilepsy group, and 0.1 mg, 0.3 mg, and 0.5 mgnimodipine groups. The incubation period, duration, and the onset of epilepsy were observed and SOD, MDA, and GSHPX of brain tissue were determined in the nimodipine group. The results were compared with those of the PTZ epilepsy group. ResultsThe onset in nimodipinepretreatment group was characterized by light seizure, prolonged incubation time, short duration and high SOD, low MDA and GSHPX. There were significantly difference between them (F＝10.720-35.831 ......

百拇医药网 http://www.100md.com/html/DirDu/2006/04/12/96/59/96.htm

您现在查看是摘要页，全文长 8861 字符。