【摘要】 目的 观察对重型颅脑损伤患者脑组织氧分压的变化情况及氧合液对变化的影响及临床意义。方法 选择重型脑损伤患者(GCS计分3～8分)80例。随机分组，治疗组40例，除采用临床综合治疗外应用氧合液，对照组40例仅采用临床综合治疗。监测脑组织氧分压、及常规临床监护。结果 伤后24h内患者PbtO2水平明显降低，24h内PbtO2水平<5mmHg者全部死亡。治疗组脑组织氧分压明显高于对照组。治疗组预后较对照组预后好，并发症少。结论 重型颅脑损伤后，PbtO2水平与预后明显相关。氧合液能够改善重症颅脑损伤引起的脑组织缺氧，改善患者预后。

    【关键词】 脑组织氧分压；颅脑损伤；氧合液

    PbtO2 level changes in severe head injury patients and effect of early application of oxygenic liquid

    MA Xue-tong，WU Hao，ZHANG Hao，et al.Wenzhou People’s Third Hospital，Wenzhou 325000，China

    【Abstract】 Objective To investigate oxygenic liquid effect on partial pressure of brain tissue oxygen (PbtO2)，and prognosis in patients with severe head injury.Methods 80 patients with severe head injury(GCS<8) were divided into control group(n=40) and treatment group(n=40).The patients in treatment group were given oxygenic liquid in addition to the common treatment received by those in control group.PbtO2 was monitored.Results PbtO2 in treatment group were obviously higher than the control.Prognosis of the treatment group were much better.Conclusion Level of PbtO2 was obviously related with prognosis.Oxygenic liquid can improve the prognosis of severe head injury. ......