Effect of Qidantongmai Tablets on calcitonin geneª²related peptide and endothelin in rats with acute myocardial ischemia

    XIE Juan, WANG Zongª²Ren, WANG Lei, PENG Liª²Jing

    1Department of Traditional Chinese Medicine, Xijing Hospital, 2Department of Pathologic Physiology, School of Basic Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To probe whether the protection of Qidantongmai Tablets (QDTMT) against myocardial ischemia in rats is related to the increasing content of plasma calcitonin geneª²related peptide (CGRP) and decreasing content of plasma endothelin (ET). METHODS: Sixty SD rats were averagely divided into 6 groups randomly: control group, model group, isosorbide mononitrate treated group, QDTMT low dosage group(QDTMTL), QDTMT medium dosage group (QDTMTM), and QDTMT high dosage group (QDTMTH). The experimental acute myocardial ischemia model was established by intraperitoneal injection of pituitrin to rats and the electrocardiogram was recorded. By means of radioimmunoassay, the contents of plasma CGRP and ET were detected. RESULTS: The contents of plasma CGRP and ET between groups had significant differences. The contents of plasma CGRP and ET in model group(58.48¡À5.00 and 120.08¡À5.72) were higher than those in the control group(50.60¡À6.53 and 51.49¡À5.47)(P<0.05). The content of plasma CGRP in each QDTMT group(63.30¡À4.10, 70.27¡À5.39, 75.86¡À4.01, from low to high dosage of QDTMT) was higher than that in the model group (P<0.05), while the content of plasma ET in each QDTMT group(101.40¡À6.10, 81.50¡À5.15, 64.14¡À4.82, from low to high dosage of QDTMT)was lower than that in the model group (P<0.05). CONCLUSION: The protection of QDTMT against myocardial ischemia may be achieved by increasing the releases of calcitonin geneª²related peptide and decreasing the content of endothelin. ......