基础卵泡刺激素和克罗米酚兴奋实验预测卵巢储备功能45例分析
卵巢储备,,卵巢储备；,血清基础卵泡刺激素；,克罗米酚兴奋实验；,不孕症,1资料与方法,2结果,3讨论,参考文献：
摘要: 目的: 探讨血清基础卵泡刺激素(FSH)和克罗米酚兴奋实验(CCT)预测不孕症患者卵巢储备功能的价值。方法： 45例不孕妇女月经第3天测定血清基础FSH水平，月经第5～9天口服克罗米酚(CC)100 mg/d,于第10天重新测定FSH水平，B超跟踪监测卵泡发育及妊娠情况。比较CCT正常与异常者的临床妊娠率及不同FSH水平者卵巢储备情况。结果：与CCT异常者相比，CCT正常者年龄明显偏小(P<0.05)，临床妊娠率明显升高(P<0.05)；与基础FSH<15 IU/L者相比，基础FSH≥15 IU/L者卵巢反应不良率明显升高(P<0.05)、优势卵泡数和临床妊娠率均明显降低(P<0.05)。结论: 基础FSH水平和CCT预测卵巢储备功能具有较高的筛选价值，可提高妊娠率。关键词：卵巢储备； 血清基础卵泡刺激素； 克罗米酚兴奋实验； 不孕症
Predictive value between basal hormone levels and clomiphene challenge
test on ovarian reserve (Analysis of 45 cases)
JIAO Yonghui, CAI Xia, SHI Min
(Department of Reproductive Medcine, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China)
Abstract: Objective: To study the predictive value of basal serum hormone levels and clomiphene challenge test (CCT) were carried out in infertile patients. Methods: Basal serum follicle stimulating hormone (FSH) levels in 45 infertile patients were measured at the third day of menses. Clomiphene 100 mg daily from day 5 to 9 was administered. FSH was tested again on day 10, dominant follicles and pregnant were monitored by trasviginal ultrasoun ography. The relationship between results of CCT and different basal FSH levels and pregnancy rates were analysed. Results: Compared with abnormal CCT patients, normal CCT patients have lower ages(P<0.05) and higher pregnancy rates (P<0.05); Compared with basal serum FSH<15 IU/L, the basal serum FSH ≥15 IU/L predicted a poor response to ovarian stimulation(P<0.05), with fewer dominant follicles(P<0.05) and lower pregnancy rates(P<0.05). Conclusion: Basal FSH level and CCT can predict the ovarian reserve and improve pregnant rate. ......
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