μ和δ阿片受体参与介导丘脑中央下核内吗啡诱发的抗伤害感受效应
丘脑中央下核,,丘脑中央下核；阿片受体；伤害感受性调制；福尔马林试验；大鼠,1Methods,2Results,3Discuss
摘要：目的 研究μ和δ阿片受体在介导丘脑中央下核(Sm)内阿片诱发的抗伤害感受效应中的作用。方法 用自动检测系统记录大鼠爪底皮下注射福尔马林诱发的伤害性行为，观察Sm内微量注射吗啡和选择性μ和δ阿片受体拮抗剂对伤害性行为的效应。 结果 吗啡(31mmol/L, 0.5μL)明显抑制福尔马林诱发的伤害性行为，这种效应可被μ阿片受体拮抗剂 βfunaltrexamine(βFNA, 0.4mmol/L, 0.5μL) 和naloxonazine(0.8mmol/L, 0.5μL)阻断，部分地被δ受体拮抗剂 naltrindole(0.4mmol/L, 0.5μL) 阻断。结论 Sm内注射吗啡诱发的抗伤害感受效应主要由μ阿片受体介导，部分地由δ受体介导。关键词：丘脑中央下核；阿片受体；伤害感受性调制；福尔马林试验；大鼠
Involvement of μ and δopioid receptors in mediating the nucleus submedius (Sm) opioidevoked antinociception
Yang Zhijie, Tang Jingshi, Jia Hong
(Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Medical Schoolof Xian Jiaotong University, Xian 710061, China)
ABSTRACT: Objective To investigate whether the μ and δopioid receptors were involved in mediating the antinociceptive effect of opioid injection into the nucleus submedius (Sm). Methods Nociceptive behavior produced by subcutaneous injection of formalin (65mmol/L, 50μL) into the hind paw of the rat was assessed quantitatively using an automated movement detection system. The effects of morphine and selective μ and δopioid receptor antagonists microinjected unilaterally into the Sm were determined in the awake rats. Results Morphine (31mmol/L, 0.5μL) depressed the nociceptive behavior elicited by formalin, and this effect was antagonized completely by the selective μreceptor antagonist βfunaltrexamine (βFNA, 0.4mmol/L, 0.5μL) and naloxonazine (0.8mmol/L, 0.5μL), and partly by the δreceptor antagonist naltrindole (0.4mmol/L, 0.5μL). Administration of morphine into thalamic regions more than 0.5 mm dorsal to the Sm had no effect on the nociceptive behavior. Conclusion Antinociceptive effects produced by opioid acting on Sm neurons are mediated mainly by μopioid receptors, and partly by δreceptors. ......
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