【摘要】 目的 探讨颈动脉粥样硬化与脑梗死及其危险因素的关系。方法 彩超检测467例前循环脑梗死患者及对照组142例非脑梗死患者的颈动脉，测量颈动脉内膜中层厚度(IMT)，观察粥样硬化斑块的有无及回声强度、数量、部位等。结果 脑梗死组中，颈动脉有粥样硬化斑块者365例，检出率为78.16%；对照组中有斑块形成30例，检出率为21.13%，两者比较差异有非常显著性(P<0.01)。颈动脉粥样硬化斑块最常见于颈动脉分叉处，以软斑多见。Logistic回归分析随着年龄增大，斑块的发生率明显增加(P<0.01)，高血压及糖尿病也是颈动脉粥样硬化斑块形成的独立危险因素(P<0.05)。结论 颈动脉粥样硬化与脑梗死的发生有密切关系，颈动脉粥样硬化的不稳定性斑块脱落是造成脑梗死的重要原因之一。

    【关键词】 颈动脉粥样硬化；脑梗死；彩色多普勒超声

    Clinical research of carotid atherosclerosis in patients with cerebral infarction

    JING Ping.Wuhan University,Wuhan 430071，China

    【Abstract】 Objective To investigate the relationship between carotid atherosclerosis and cerebral infarction and the relative factors.Methods 467 cases of anterior circulation infarcts served as cerebral infarction(CI) group and 142 cases of non cerebral infarction as control group.In both groups,the intima media thickness(IMT) of the carotid arteries,and the nature,number,location of carotid atheromatous plaque were assessed by color Doppler ultrasonography.Results Significant differences of the detectable rate of carotid atheromatous plaque was found between CI group [78.16%,365cases] and control group [21.13%,30 cases](P<0.01).The atheromatous plaques were common in bifurcation of common carotid artery,and the plaques of fibrous and fatty were common.By Logistic regression analysis,we found carotid plaque increased progressively with age(P<0.01).Diabetes and high blood pressure were conformed to be independent risk factors for carotid atherosclerosis plaques(P<0.05).Conclusion Carotid atheromatous plaques is closely related to cerebral infarction.One important cause of cerebral infarction is from soft plaque broken in carotid atherosclerosis. ......