人类同种异体肝移植慢性排斥反应病理特点分析
肝移植,,肝移植;,慢性排斥反应;,病理诊断,1材料与方法,2结果,3讨论,参考文献:
摘要：目的： 观察肝脏移植后慢性排斥反应的病理特征,了解慢性排斥反应的诊断及鉴别诊断要点。方法： 穿刺肝活检组织经10%中性福尔马林固定，常规HE染色,观察病理切片。结果： 肝移植后慢性排斥反应可见肝小叶中央静脉周围肝细胞消失、坏死、出血、纤维化,部分伴有肝细胞淤胆、气球样变性,但未见胆管消失及阻塞性动脉病。结论: 慢性排斥反应的诊断必须依据临床、实验室及组织病理学检查。中央静脉周围的改变也许可以提示慢性排斥反应的发生。关键词： 肝移植; 慢性排斥反应; 病理诊断
Histopathologic analysis of chronic rejection after orthotopic liver transplantation
ZHANG Wei, WEN Hao, LIU Xia
(Department of Pathology and General Surgery, First Affiliated Hospital,Xinjiang Medical University, Urumqi 830054, China)
Abstract: Objective: To observe histopathologic characteristics of chronic rejection of posttransplantation liver and to understand the diagnosis and differentiated diagnosis. Methods: Liver biopsies were analyzed by using routine HE staining, combined with VG, Masson, and PAS staining if necessary. Result: Histopathologic chronic rejection in liver biopsies might include perivenular hepatocyte dropout, necrosis, hemorrage or fibrosis, sometimes accompanied by hepatocyte ballooning or cholestasis. but without cholangitis and obliterative arteriopathy. Conclusion: The diagnosis of chronic rejection in allograft liver must be based on data of clinic, laboratory and histopathology. Changes around central vein might indicate the occurance of chronic rejection. ......
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