Combined detection of AFP, CEA, CA19ª²9 and CA125 in diagnosing malignant tumors of digestive system

    GU Yong, DUAN Wei, WU Xiuª²Hua, HE Liª²Hong

    1Department of Gastroenterology, 2Medical Section Shaanxi Provincial Corps Hospital Chinese People¬ðs Armed Police Forces, Xi¬ðan 710054, China

    ¡¾Abstract¡¿ AIM: To study the value of combined detection of AFP, CEA, CA19ª²9 and CA125 in the diagnosis of malignant tumors of digestive system. METHODS: Totally 120 cases affirmatively diagnosed by pathological analysis as malignant tumor of digestive system were subjected to the study, including 36 cases of liver cancer, 32 cases of gastric cancer, 28 cases of pancreatic cancer and 24 cases of colon cancer. Totally 119 cases of corresponding benign diseases were used as controls, including 35 cases of cirrhosis, 40 cases of peptic ulcer, 23 cases of pancreatitis and 21 cases of ulcerative colitis. Radioimmunoassay was used to detect the content of AFP, CEA, CA19ª²9 and CA125 and analyze their sensitivity, specificity and accuracy. RESULTS: The contents of AFP, CEA and CA19ª²9 in liver cancer were significantly higher than those in cirrhosis (P<0.05 or P<0.01), while CA125 was not significantly different (P>0.05). The contents of CEA, CA19ª²9 and CA125 in gastric cancer, pancreatic cancer and colon cancer were significantly higher than those in controls, while AFP had no statistical difference (P>0.05). The sensitivity and accuracy of combined test of AFP, CEA, CA19ª²9 and CA125 were respectively 91.7% and 83.1% in liver cancer, 89.3 % and 79.2% in pancreatic cancer, 83.3% and 82.4% in colon cancer, 78.1% and 82.2% in gastric cancer. Totally the sensitivity was 85.8% and the accuracy was 81.6%. CONCLUSION: The combined analysis of AFP, CEA, CA19ª²9 and CA125 significantly improves the detectable rate and the diagnostic accuracy of malignant tumors of digestive system. ......