摘要：目的研究和络舒肝胶囊对小鼠日本血吸虫病肝纤维化的治疗作用及其机理, 并与吡喹酮的作用对比。方法80只小鼠随机分为4组。其中3组小鼠感染日本血吸虫8周后，分别以和络舒肝胶囊0.1粒/只/d治疗8周、吡喹酮500 mg·(kg·d)-1治疗2 d以及不作任何治疗(实验对照组)，第4组小鼠作为正常对照组。应用免疫组化染色及HE染色法，观察和分析和络舒肝胶囊及吡喹酮治疗前后各组小鼠肝组织病理改变及血小板衍生生长因-BB (platelet-derived growth factor, PDGF-BB)和Ⅰ，Ⅲ型胶原的表达变化。结果和络舒肝胶囊治疗后肝纤维化组织病理损伤减轻，PDGF-BB和Ⅰ，Ⅲ型胶原含量均明显低于实验对照组(P<0.01)和吡喹酮组(P<0.01或P<0.05)。结论和络舒肝胶囊对小鼠日本血吸虫肝纤维化具有较好的治疗作用，其远期抗肝纤维化效果优于吡喹酮。

    关键词：和络舒肝胶囊； 日本血吸虫病； 肝纤维化； 血小板衍生生长因-BB； 胶原

    Therapeutical Effects and Mechanisms of Heluoshugan Capsule on Schistosome-infected Mice with Liver Fibrosis

    XU Biao

    (Department of Infectious Diseases, Puai Hospital of Tongji Medical College, Huazhong University of Science and Techology, Wuhan 430033,China)

    Abstract:ObjectiveTo study the therapeutical effects and mechanisms of Heluoshugan capsule on schistosome-infected mice with liver fibrosis. Compare the effects with praziquantel.MethodsEighty mice were divided into four groups: three groups were infected with Schistosoma japonicum. After eight weeks, one group was treated with Heluoshugan capsule 0.1capsule per mice every day for 8 weeks, one group was treated with praziquantel 500mg/(kg·d) for 2 days and the other was taken as experimental control without any treatment. The fourth group was taken as normal control. Immunohistochemical technology and HE staining were applied to observe the content of hepatic PDGF-BB ......