Association of polymorphisms of transforming growth factorª²beta 1 gene with susceptibility to essential hypertension in Zhuang nationality of Guangxi province

    WEI Yeª²Sheng1,LI Zhuang1,LAN Jingª²Sheng2

    1Clinical Laboratory Center,2Department of Cardiovasology,Affiliated Hospital,Medical College for Youjiang Nationality£¬Baise 533000,China

    ¡¾Abstract¡¿ AIM: To study the relationship of the polymorphisms of transforming growth factorª²beta 1 (TGFª²¦Â1)gene+869T/C and +915G/C in the exon 1 with essential hypertension in population of Chinese Zhuang nationality.METHODS: The polymorphisms of TGFª²¦Â1 gene were analyzed by sequence specific primersª²polymerase chain reaction (PCRª²SSP) methods in 172 patients with essential hypertension and 180 healthy controls.RESULTS: The TGFª²¦Â1 gene +869T/C polymorphism was significantly different between the two populations.The relative risk of suffering from essential hypertension of T allele was 1ª±525 times that of C allele(OR =1ª±525,95% CI:1ª±133¡«2ª±053).The systolic blood pressure level of TGFª²¦Â1 C allele carriers was significantly higher than that in nonª²carriers(22ª±0¡À3ª±9 kPa vs 21ª±1¡À3ª±1 kPa,P<0ª±05).But the polymorphism distributions of TGFª²¦Â1 gene +915G/C polymorphism was not different between the essential hypertension group and the control group.CONCLUSION: TGFª²¦Â1 gene +869T/C polymorphism is associated with essential hypertension and C allele may be a risk factor for essential hypertension.The TGFª²¦Â1 C allele carriers may have increased risk of essential hypertension by enhancing the systolic blood pressure. ......