Effects of laparoscopic ovarian drilling on growth hormone/insulinª²like growth factorª²1 axis in women with refractory PCOS

    CHEN Jing,XU Wangª²Ming,YANG Jing

    Reproduction Center,People¬ðs Hospital£¬Wuhan University,Wuhan 430060,China

    ¡¾Abstract¡¿ AIM: To assess the effect of ovarian drilling under laparoscopy on the growth hormone/insulinª²like growth factorª²1 axis in women with refractory polycystic ovary syndrom (PCOS) and its main clinical mechanism.METHODS: We chose 30 women with PCOS with clomiphene resistance as PCOS group and 30 women with regular cycles as control group, who matched in age and body mass index.We compared the serum hormone level between PCOS group and control group.Laparoscopic ovarian drilling was performed in PCOS group.The serum was obtained before and 3 months after intervention and the hormone level was compared to determine whether the growth hormone (GH) levels was associated with other serum indices.RESULTS: The PCOS group had lower GH levels and higher IGFª²¢ñ levels compared with those of conrol group (P<0ª±01).The surgical treatment in PCOS group obviously increased the GH and reduced the IGFª²¢ñ (P<0ª±01).The basal GH was correlated positively only with testosterone before operation (r = -0ª±58,P<0ª±01),but after operation it was correlated positively with testosterone and androstenedione (PT<0ª±01,PA<0ª±05).CONCLUSION: The GHª²IGFª²¢ñ axis of women with PCOS reverses after laparoscopic ovarian drilling,which attributes mainly to the decreased androgens levels.Some ovarian cytokines and growth factors may also play some important roles. ......