孤啡肽在大鼠胃肠道的分布及意义
孤啡肽,,孤啡肽;肠肌丛;肠神经系统;免疫组织化学,1材料和方法,2结果,3讨论,【参考文献】
Distribution of nociceptin/orphanin FQ in gastrointestinal tract of rat and its significanceLI HaiYan1,YAN Xiang1,GUO YingFang2,WANG JinYang1,WANG Hong3
1Department of Geriatrics,First Affiliated Hospital,Lanzhou Medical College,2 Department of Pathology,Peoples Hospital of Gansu Province,Lanzhou 730000,China,3 Department of Gastroenterology,Hospital of Jinchuan Coorperation Company,Jinchang 737100,China
【Abstract】 AIM: To investigate the distribution of nociceptin/orphanin FQ,endogenous opioid receptor like 1 receptor (ORLI) ligand,in the gastrointestinal tract of rats.METHODS: Immunohistochemical staining (SP method) was used to determine the presence and distribution of nociceptin/orphanin FQ in the esophagus,stomach,small intestine,proximal colon and distal colon of rats.RESULTS: Orphanin FQ immunoreactive (OFQIR) neurons and nerve fibers were visualized in the myenteric plexus of esophagus,stomach,intestine and colon of rats.CONCLUSION: Orphanin FQ is widely distributed in the enteric nervous system of the rat. It may be involved in the gastrointestinal motility,endocrine,mucosa blood stream and immunity of the gastrointestinal tract. ......
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