摘要 :目的 研究小型猪心肌缺血模型制备的麻醉及管理方法。 方法 氯胺酮基础麻醉后，硫喷妥钠诱导经口气管插管静脉普鲁卡因复合全麻。 结果 实验猪对氯胺酮基础麻醉有较大的耐受量。保留呼吸平均气管插管次数(2.3±0.7)次。心脏操作时心电图变化较大。 结论 对实验猪进行保留呼吸气管内插管全身静脉麻醉是可行的。心脏操作容易出现心律失常，可预防性应用利多卡因和提醒术者轻柔操作，若麻醉处理得当，可保证围术期猪的安全。

    关键词 :麻醉，小型猪;模型，心肌缺血

    Anesthetic management of making myocardial ischemia model in minitype pigs

    PENG Sheng，LIU Gong-jian，WANG Guang-lei，et al

    (Jiangsu Provincial Key Laboratory of Anesthesiology，Xuzhou Medical College，Xuzhou，Jiangsu221002，China)

    Abstract:Objective To study the anesthesia in making myocardial ischemia model in minitype pigs.Methods Pro-caine intravenous anesthesia was administered after ketamine basal anesthesia，pentothal sodium induction and intubation.Re-sults Ketamine for basal anesthesia was better tolerated by pigs than by humans.(2.3±0.7)trials in average were needed to achieve a successful intubation.Dramatic fluctuations in ECGwere encountered during the heart operation.Conclusion Intra-tracheal intubation and intravenous anesthesia is practicable in the open-heart operation on minitype pigs.Soft manipulation over the heart and prophylactic use of procaine are suggested to avoid surgically-induced arrhythmia.Adequate anesthesia is key to the pit′s safety in the perioperative period. ......