Protective effects of Qidantongmai tablets on injured rat vascular endothelial cells

    WEI Liª²Qiang1,WANG Zongª²Ren1,WANG Lin2,MA Jing1,WANG Yingª²Mei3,MA Shiª²Ping1

    1Department of Traditional Chinese Medicine,2Department of Dermatology,3Department of Pathology,Xijing Hospital,Fourth Military Medical University,Xi¬ðan 710033,China

    ¡¾Abstract¡¿ AIM: To investigate the protective effects of Qidantongmai tablets on injured rat vascular endothelial cells (VEC) and to further explore the mechanisms of blood stasis and blood circulation promotion and blood stasis removal.METHODS: A model of blood stasis with endothelial damage was established by giving rats an injection of adrenaline.The numbers of circulating endothelial cells (CEC) in whole blood and hemorheology were then investigated and transmission electron microscope was used to observe the alteration of the ultrastructure of descending aorta of rat vascular endothelial cells.The protective effects of Qidantongmai tablets were observed.RESULTS: The number of CEC increased,accompanied with abnormal whole blood viscosity and pathological changes of the VEC,such as swelling,necrosis and shedding.Qidantongmai tablets reduced the number of CEC in rats with blood stasis syndrome and improved the structure of VEC in rats with endothelial damage.CONCLUSION: The rats with blood stasis syndrome have obvious injury of vascular endothelial cells and Qidantongmai tablets have some protective effects on vascular endothelial cells. ......