四顺清凉饮长期毒性的研究
四顺,,四顺清凉饮；,长期毒性,1材料与方法,2结果,3讨论,参考文献：
摘要：目的观察四顺清凉饮长期连续灌胃给药对大鼠所产生的毒性反应。方法取5～8周龄SD大鼠随机分成高、中、低剂量组和对照组，每组各20只，♀♂各半。灌胃1次/d，给药期为3周。每天观察动物情况，每3 d测量体重，在给药3周和停药6 d后各取部分动物作全面检查。结果对照组及各用药组大鼠自始至终活动正常，生长良好，食欲正常。在血液学、血液生化指标、尿常规和病理检查方面均未发现与药物呈剂量相关性的异常变化。病理学检查动物心、肝、脾等组织无异常病理变化。结论长期口服四顺清凉饮无明显的毒性反应。关键词：四顺清凉饮； 长期毒性
The Rat Chronic Toxicity Test of Sishun Qingliangyin
ZHU Liang， XING Shaojing， WANG Yifei， YANG Ke， LI Jiuxiang
(Biomedical Research and Development Center of Jinan University, Guangzhou 510632, China)
Abstract:ObjectiveTo observe the effects of Sishun Qingliangyin on the rat chronic toxicity test.MethodsThe rats were orally given for 3 weeks with the doses of 40, 28 and 19.6 g/kg( being 44.8,31.4 and 22 times of clinic dose) and for 6 days of stopping administration, the rat weights, organ coefficients, the indexes of hematology and biochemistry were determined, and the pathological examination were carried out.ResultsThe outer appearance and behavior, weights, organ coefficients, the indexes of hematology and biochemistry in rats has no significant difference by comparing with control group; the pathological examination was not discovered significant pathological changes with relation of drug toxicity and the delayed toxicity reaction in stopping administration later. ConclusionThe Sishun Qingliangyin has no significant toxicity for long-term administration in rats, and infers that the drawing up doses in clinic will be safe. ......
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