中药肠炎清治疗小鼠葡聚糖硫酸钠所致结肠炎的机制
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吕永慧, 胡品津, 陈文红, 毕向军, 庞瑞萍
溃疡性结肠炎;葡聚糖硫酸钠;肠炎清;TNF-α;IL-1β;IL-6,吕永慧,胡品津,陈文红,毕向军,庞瑞萍,通讯作者,Therapeuticmecha
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吕永慧, 广州市中医医院消化内科 广东省广州市 510130
胡品津, 陈文红, 毕向军, 庞瑞萍, 中山大学附属第一医院消化内科 广东省广州 510080
通讯作者: 吕永慧, 510130, 广东省广州市, 珠玑路16号广州市中医医院消化内科. zdjlyh@126.com
电话: 020-81886504-1401
收稿日期: 2006-04-06 接受日期: 2006-04-28
Therapeutic mechanism of Changyanqing in treatment of colitis induced by dextran sulfate sodium
Yong-Hui Lü, Pin-Jin Hu, Wen-Hong Chen, Xiang-Jun Bi, Rui-Ping Pang
Yong-Hui Lü, Department of Gastroenterology, Hospital of Traditional Chinese Medicine, Guangzhou 510130, Guangdong Province, China
Pin-Jin Hu, Wen-Hong Chen, Xiang-Jun Bi, Ruiping Pang, Department of Gastroenterology, the First Affiliated Hospital of Zhongshan University, Guangzhou 510080, Guangdong Province, China
Correspondence to: Yong-Hui Lü, Department of Gastroenterology, Hospital of Traditional Chinese Medicine, 16 Zhuji Street, Guangzhou 510130, Guangdong Province, China. zdjlyh@126.com
Received: 2006-04-06 Accepted: 2006-04-28
Abstract
AIM: To investigate the therapeutic effects of Changyanqing on dextran sulfate sodium(DSS)-induced colitis and its mechanism.
METHODS: DSS was used to establish the model of experimental colitis in 40 mice. Then the mice were averagely randomized into 4 groups (A, B, C, and D). The mice in group A, B, and C were treated withChangyanqing, salicylazosulfapyridine (SASP), and Changyanqing + SASP, respectively, and those in group D served as controls. Changyanqing was administratered by gastric irragation at a dose of 0.2 mL/(20g•d) for 7 d. The disease activity index (DAI) and the activity of intestinal myeloperoxidase (MPO) were observed. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6 mRNA were detected by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR).
RESULTS: In comparison with those in the controls, the DAI (1.413 ± 0.835 vs 2 ......
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