乳腺癌组织中STAT3激活的意义
乳腺肿瘤,,乳腺肿瘤；信号转导和转录激活因子3；凝胶电泳迁移率分析,1材料和方法,2结果,3讨论,【参考文献】
Significance of activation of STAT3 in human breast cancer tissueTU Gang, YAO ZhenXiang
Department of General Surgery, First Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China
【Abstract】 AIM: To investigate the relationship between the activation of signal transducers and activatiors of transcription 3 (STAT3) in breast tumor tissues and adjacent tissues and the clinical stages of breast cancer. METHODS: The expressions of STAT3 protein in breast tumor tissues and adjacent tissues were measured by immunohistochemistry and STAT3 DNA binding activity was examined by electrophoretic motility shift assay (EMSA)in 36 breast cancer patients. RESULTS: STAT3 DNA binding activity in tumor tissues was higher compared with that in adjacent tissues in clinical stage of ⅡA, ⅡB and ⅢA(all P<0.01). The DNA binding activity of STAT3 in breast cancer was not associated with the clinical stage(P>0.05). The STAT3 protein was mainly expressed in cytoplasm and nucleus of breast cancer cells. CONCLUSION: STAT3 may play an important role in the development of breast cancer. Inhibition of STAT3 activity may be a new therapy for breast cancer. ......
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