MS23对大鼠胸主动脉环舒张作用的研究
MS23,,],MS23；氯化钾(KCl)；去甲肾上腺素(NE)；动脉环,1材料与方法,2结果,3讨论,4结论,参考文献：
[摘 要] 目的：探讨MS23舒张血管平滑肌作用及其机制。方法：采用离体血管张力实验方法，观察MS23的舒血管作用和对不同浓度KCl引起大鼠胸主动脉环收缩作用的影响。结果均用±s表示。资料分析：加用MS23前后进行配对t检验。制图用Graph Pad Prism4 Demo软件。统计分析用SPSS11.5软件。P<0.05为有统计学意义。结果:高浓度的MS23可降低血管环的静息张力(P<0.05)；MS23对KCl(60 mmol/L)和NE(1×10-5)mol/L)引发的血管环收缩具有拮抗作用(P<0.01)；MS23能使20 mmol/L~70 mmol/L KCl对动脉环收缩作用减弱或明显减弱(P<0.05或P<0.01)；随着MS23浓度的增加，其作用逐渐增强，KCl的浓度效应曲线向右下移位：半数有效浓度有增加(P<0.05或P<0.01)。结论:高浓度的MS23可减小动脉环的静息张力；MS23可抑制KCl和NE引起的缩血管作用；MS23对动脉环的舒张作用随着其浓度的增加而增强，MS23对KCl收缩血管作用的抑制不是竞争性抑制。[关键词] MS23；氯化钾(KCl)；去甲肾上腺素(NE)；动脉环
The Effects of MS23 on Isolated Rat Thoracic Aorta Rings
XIANG Xiaojun1,LV Jiyuan2,ZHANG Mingsheng3，et al
(1.Yuncheng Emergency Centre,Yuncheng， Shanxi 044000,China;2.The 1st Hospital of Shanxi Medical University,Taiyuan， Shanxi 030001,China;3.The Medical University of Shanxi,Taiyuan, Shanxi 030001,China)
Abstract：Objective To study the mechanisms of MS23 on vessel smooth muscle cell by means of the observation of MS23 on high K+ contracted or norepinphrine(NE)contracted the isolated rat thoracic aorta rings on this experiment.Methods The effects of the drugs on rat isolated thoracic aortic rings' contraction induced by KCl with different consistencies or by norepinphrine(NE) were observed with MS4000 computer system.The rings were isolated from Wistar rats, which were 250280 grams heavy.Results MS23 can relax the resting tone of the isolated rat thoracic aortic rings at high consistency (P<0.05).MS23 produced relaxations of the high K+ contraction and norepinphrine(NE)contraction on aortic rings of rats(P<0.01).The relaxations to KCl are progressive enhancing with the increasing consistency of MS23.The quantityeffect curve of KCl moves right and down and the EC50 of KCl were growing with the consistency of MS23 increasing.Conclusion MS23 can decrease the resting tone of the isolated rat thoracic aortic rings at high consistency, MS23 showed relaxations on the high K+ contraction or norepinphrine(NE)contraction and the relaxations are progressive weakening with consistency increasing. ......
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