汉族群体血管紧张素原基因T174M多态性与心肌梗死相关
心肌梗死,,心肌梗死;血管紧张素原;基因;聚合酶链反应;限制性片段长度多态性,1材料和方法,2结果,3讨论,【参考文献】
Polymorphism of angiotensinogen gene is associated with myocardial infarction in Chinese Han populationZHANG AnPing1,NING ShuCheng1,LI ZhanQing2,YI Xue2
1Department of Cell Biology,School of Biology,2Department of Cardiovasology,Affiliated Hospital,Coal Medical College of North China,Tangshan 063000,China
【Abstract】 AIM: To study the association of a molecular variant of angiotensinogen AGT (T174M) gene with myocardial infarct (MI) in Chinese Han population.METHODS: AGT (T174M) allele was determined by polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP).RESULTS: The frequencies of AGT (M174) allele (167%) and 174MM genotype (76%) in the MI group were higher than those in the control group (149% and 945% respectively, χ2=757, P<0025 and χ2=579,P<005),AGT gene 174MM genotype was an significantly increased risk factor of MI (odds ratio 366,P=0.018) .CONCLUSION: AGT (T174M) may be an independent risk factor for MI in Chinese Han population. ......
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